الفهرس 
The protective effect of Moringa oleifera extract on rat lung tissue exposed to cypermethrin pesticide
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Abstract
Introduction: Creatures face a massive problem with global pesticide exposure. Moringa oleifera (MO) has countless health advantages as a medicinal herb. The objective of this study was to examine the role of Moringa oleifera leaves extract (MOLE) in controlling the lung injury caused by cypermethrin (CYP). Method: The experimental animals divided into six groups: G}: control group, G}} and G}}} received by oral gavage (1/10thLD₅₀) and (1/30thLD₅₀) of CYP pesticide respectively for 28 days. G}V: received (250 mg/Kg/day) of MOLE. GV and GVI were orally administered (1/10th LD50 of CYP and 250 mg/Kg/day of MOLE) and (1/30th LD₅₀ of CYP and 250 mg/Kg/day of MOLE) respectively for 28 days. group }V, group V and group V} have given MOLE orally (250 mg/kg/day) for 14 days prior to the experiment and during it (28 days). Samples of lung tissues were taken and utilized for gene expression, comet examination, biochemical and histopathological investigations. Results: The results revealed an increase in MDA level, SOD, CAT, GST activities in addition to a decline in GSH content in rats’ lungs upon CYP exposure. Additionally, CYP induced lung apoptosis and marked DNA damage. The histopathological changes confirmed lung injury. However, co-administration of MOLE alleviates the injurious effect of CYP. Conclusion: these data suggest that MO, with its protective effects, maybe a potential compound for the prevention of CYP-induced lung injury