الفهرس 
Title: Efficacy and Safety of intravenous Oxytocin versus Tranexamic acid in reducing blood loss during abdominal myomectomy; A randomized controlled trial
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Abstract
Objectives: The aim of this study was to compare the efficacy and safety of intravenous oxytocin versus IV Tranexamic acid (TXA) in reducing intraoperative blood loss during open myomectomy. Design:A randomized controlled trial (RCT). Setting: Kasr Alainy hospital Obstetrics and Gynecology department, Cairo University, Egypt,during the period from May 2019 to April 2021. Methods: A total of 75 patients with uterine fibroid fulfilling the inclusion criteria were scheduled for abdominal myomectomy. Patients were randomized into 3 equal groups (25 patients each). In the three groups the following outcomes were reached: the estimated blood loss (EBL) during open myomectomy, need for intra and postoperative blood transfusion, operative time,myomectomy time, postoperative hematocrit and hemoglobin , DROP in postoperative hemoglobin ,DROP in hematocrit, side effects of TXA and oxytocin including and postoperative stay in days. Interventions :group (A) (Tranexamic Acid group): Women received TXA as a single bolus intravenous injection of 10 mg/kg (maximum 1g) slowly over 0 to 15 min before skin incision, followed by a continuous infusion of 1 mg/kg/h dissolved in 1 L of saline for 6 h (maximum 1g /6 h). group (B) (Oxytocin group): Women received 10 IU oxytocin in 500 ml saline at a rate of 120 ml/h 5 minutes before induction of anathesia and during the course of the operation.group (C) (placebo group): Women received 500 ml saline infusion at a rate of 120 ml/h before and during the operation Results:patients in TXA group had significantly lower intra operative blood loss than control group (222.16 ml ±29.55 ml versus 570.46 ml ±53.46 ml; p <0.001). Likewise, patients in Oxytocin group had significantly lower intra operative blood loss than control group (234.52 ml ±28 mlversus 570.46 ml ±53.46 ml; p <0.001)