الفهرس 
Taxonomy and mycologyOnly 14 pages are availabe for public view
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Abstract
A total of 194 Candida isolates were recovered from samples collected from different departments of Tanta University Teaching Hospitals and identified to the species level using chrOMagar Candida. Confirmation of identity was performed using MALDI-TOF/MS. Isolates were subjected to antifungal susceptibility testing using the clinical breakpoints provided by EUCAST (2015) guidelines in order to select MDR Candida isolates. MDR Candida isolates (53 isolates) were subjected to MIC determination of antifungals using broth microdilution method. The minmum inhibitory concentrations (MICs) of eight antifungal agents including; itraconazole, fluconazole, griseofulvin, amphotericin B, terbinafine, miconazole, nystatin and caspofungin were determined. Amphotericin B was found to be the least active antifungal drug against Candida isolates where its incidence of resistance was 74.8% and MIC values ranged between 1 and 16 μg/ml. Also, it was found that MIC values of fluconazole ranged between 2 and 256 μg/ml against C. albicans isolates compared to its breakpoint (≥ 8 μg/ml) indicating high level of azole resistance. On the other hand, all tested Candida spp. isolates were susceptible to caspofungin. Data also revealed that MIC values of farnesol against test isolates ranged between 0.29 and 150 μM while those of tyrosol ranged between 2750 and 5500 μM.