الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
This study summarized that EBV miRNA BHRF1-1 expression levels were
significantly higher in the B- lymphocytes of patients with CLL compared with healthy
individual(p<0.001).It was found that the eopression levels of BHR 1-1 in chronic B- Lymphocytic Leukemia patients were positively associated with advanced Rai stages and observed a correlation between higher BHRF1-1 expression levels and shorter survival. Furthermore, in the majority of CLL cases where BHRF1-1 was exogenously induced in primary malignant B cells the levels of TP53(17 p del) were reduced (Li et al., 2012; Fabbri and Croce, 2011). Our findings suggest that EBV may have a role in the process of disease progression in CLL and that miRNA RT-PCR and miRNAs ISH could represent additional methods to detect EBV miRNAs in patients with CLL. Our observation that all the patients with CLL express EBV miRNAs at high levels and therefore experienced infection with the virus is an interesting finding. The mechanism(s) behind this miRNA expression are under evaluation in Salamanca university (Spain) and Tanta university laboratories and once deciphered will help us to better understand the EBV iral cycle. Furthermore, if confirmed in large prospective studies, our data will support the introduction in clinical practice of miRNA-related EBV diagnostic tests.