الفهرس | Only 14 pages are availabe for public view |
Abstract Anemia occurs frequently in patients with chronic kidney disease (CKD) and its prevalence increases as CKD progresses (1). Anemia impacts on the morbidity and mortality of CKD patients by accelerating disease progression and decreasing survival(2). Key mechanisms for the pathogenesis of anemia in CKD involve a relative deficiency of erythropoietin, iron deficiency and misdistribution, increased blood loss, and shortened erythrocyte life span (3). The underlying causes of iron deficiency anemia (IDA) are chronic blood loss occurring during phlebotomy, blood trapping in the dialysis apparatus, chronic bleeding from uremia-associated platelet dysfunction and impaired dietary iron absorption. In addition to the absolute iron deficiency, functional iron deficiency (FID) also develops in patients on hemodialysis (HD) (4). Optimal treatment of (IDA) is an important component of care for HD patients, with numerous benefits such as higher tolerance for physical activity, improved cognitive. |