الفهرس 
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Abstract
Drug induced nephrotoxicity is defined as the presence of any kidney injury caused by medications. These injuries include sclerosis of the renal glomeruli, widening of the Bowman’s capsule, interstial fibrosis, and tubular cell necrosis. Acute kidney injury(AKI)occurs in about 25%-40% of cases treated with cisplatin, but chronic renal injury of high grades 3 or 4 is estimated to be up to 8.5%.
The aim of the present work was to study the possible protective effect of PRP on renal structure in cisplatin- induced nephrotoxicity in adult male albino rats. PRP was used as a blood product rich of growth factors in a trial to enhance renal tissue and functions.
The present study was carried out on thirty-five albino rats. Thirty adult male rats were used as the experimental group. Five age-matched healthy male albino rats were used to obtain the PRP.
The thirty adult male albino rats were randomly assigned to three groups:
group I: (Control group) includes ten adult male albino rats received sterile sodium chloride solution 0.9% (1mL, single dose) by intraperitoneal injection on the first day as a placebo.
group II: (cisplatin treated group) includes ten rats received cisplatin (7.5 mg/kg, single dose) by intraperitoneal injection on the first day and euthanized under anesthesia after 14 days from cisplatin injection.
group III: (cisplatin+PRP treated group) includes ten adult male albino rats received cisplatin (7. 5 mg/kg, single dose) by intraperitoneal injection on the first day of experiment and received platelet –rich plasma (1 ml, single dose) by intraperitoneal injection after injection of cisplatin by 24 hours and euthanized under anesthesia after 14 days from cisplatin injection.