الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Hepatic fibrosis is a wound-healing response to multiple types of chronic liver disease and injury. Liver fibrosis in chronic liver disease results from excessive accumulation of an extracellular matrix in response to chronic inflammation (Taouli et al., 2007). Beyond being a marker of hepatic injury, fibrosis appears to play a direct role in the pathogenesis of cirrhosis, hepatocellular carcinoma, and portal venous hypertension, leading to increased morbidity and mortality. Viral hepatitis C infection represents the most common cause of hepatic fibrosis in Egypt (Castera, 2012). Liver biopsy is the reference standard for diagnosis and staging of fibrosis. However, it is an invasive technique that assesses a small part of the liver, relies on a subjective histopathologic evaluation which is vulnerable to inter- and intra-observer variability (Regev et al., 2002). Non-invasive early diagnosis and accurate staging of fibrosis and allows for prompt treatment. Multiparametric MRI, including DWI, has the potential to become a method of virtual liver biopsy for diffuse liver diseases (Van Beers et al., 2017).