الفهرس 
Risk factors for obesity
Association between obesity and T2-DMOnly 14 pages are availabe for public view
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Abstract
Obesity is a metabolic disorder which could be a cause of type 2 diabetes mellitus (T2-DM) development. Metformin (Met) is anti-diabetic drug for T2-DM-patients and sometimes used to decrease the overweight in obese persons. This study was conducted to evaluate the effect of the prolonged treatment with Met on the renal functions in both of obese and T2-DM-rats. Sixty (60) adults’ male rats were used to conduct the experiments. Rats were divided into 6 groups (n=10). To induce obesity, rats were fed on high fat diet (HFD) for 5-weeks. Additionally, to induce T2-DM (HFD/STZ diabetic rats), rats fed on HFD were injected with a single dose of streptosotizine (STZ) (40 mg/kg). Groups of obese or HFD/STZ diabetic rats were administered orally with Met (150 mg/kg) for two months. To evaluate the effect of the long time Met treatment in obese and T2-DM rats, kidney functions, oxidative stress biomarkers (SOD, CAT, GSH and MDA), C-peptide, glucose levels and histological alterations in kidney tissues were determined. Treatment of rats with Met for 30-days did not change the previous biochemical parameters, however, treatment of obese rats with Met induced toxic effect in the renal functions evidenced by the increase the levels of urea and creatinine. Furthermore, treatment of obese rats with Met decreased SOD, CAT, activities, and GSH levels and increased the MDA level in the rats’ kidney tissues. In contrast, in T2-DM-rats, Met did not show a toxic effect on the renal functions. In summary, administration of Met in obese rats led to toxic effect on the kidney, however, treatment of T2- DM-rats with Met did not cause potential side effects on the renal functions. Keywords: Diabetes mellitus, Hyperglycemia, Obesity, Metformin, Hepato-renal function.