الفهرس 
Pregnancy loss (miscarriageOnly 14 pages are availabe for public view
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Abstract
Abstract
Background: Early pregnancy loss is a common obstetric complication and is often preceded by vaginal bleeding. It is estimated that as many as 12% to 15% of all clinically recognizable pregnancies and up to 22% of all pregnancies end in miscarriage. Aim of the Work: to prove the role of vaginal blood alpha-fetoprotein as a marker for detection of early inter-uterine pregnancy failure. Patients and Methods: This observational cross-sectional study was conducted at Ain Shams University Maternity Hospital during period time from February 2020 to September 2020 on a total of 30 women with possible early pregnancy failure. This study was done after approval of the ethical committee of the department of obstetrics and gynecology, faculty of medicine, Ain Shams University. Laboratory specimens, evaluation forms and reports were maintained in a confidential way. The study was based on the investigator self-funding. Results: Paired comparisons between serum and vaginal AFP in both groups showed a statistically highly significant difference (with a big median difference) in the missed miscarriage group, and a significant difference (yet with a small median difference) in the cerclage group. Conclusion: Vaginal blood AFP concentration would reliably diagnose an IUP failure. Our conclusion from this study is that the higher the [AFP]vaginal blood/[AFP] maternal serum ratio, the more likely the diagnosis of a failed IUP with the actual passage of embryonic/fetal tissue.