الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Gestational diabetes mellitus (GDM) is connected to macrosomia, newborn hypoglycemia, premature delivery, or neonatal hyperbilirubinemia, as well as a greater risk of preeclampsia, dystocia, and long-term consequences including type II diabetes mellitus in the mother.
As a result, early diagnosis of the risk of developing GDM is critical for preventing the disease and the health implications that come with it. Most GDM guidelines and recommendations, on the other hand, propose screening for GDM at 24–28 weeks of pregnancy since existing data is insufficient to support it before then in asymptomatic pregnant women.
The current study’s objective is to investigate the correlation between concentrations of serum ferritin in the 1st trimester of pregnancy and GDM diagnosis in high-risk pregnant female, so as to give novel ideas for the early detection and prevention of GD.
This study was conducted on high-risk pregnant women after receiving clearance from the Alexandria Faculty of Medicine’s ethical committee (sample size: 50). At 10-12 gestational weeks, the serum ferritin concentration and fasting blood glucose were determined, and a 75g oral glucose tolerance test was done at 24-28 weeks. The pregnant women were separated into two groups based on the obtained results of the oral glucose tolerance test: GDM and normal control. (Prospective control study)
BMI and high ferritin levels were shown to have a significant connection with developing GDM in the research group. This research discovered a link between fat accumulation and persistent low-grade inflammation in the body. As a result of the increased serum ferritin production, serum ferritin is an excellent indicator of inflammation. As a result, it is obvious that obesity has a significant part in developing of diabetes, as evidenced by elevated ferritin levels.