الفهرس 
Aim of the workOnly 14 pages are availabe for public view
 |  | from | 114 |  |  |
| | | from | 114 | | |
Abstract
Obesity in childhood is the main determinant of whole body reduced insulin sensitivity. This association has been demonstrated in multiple adult and pediatric cohorts. The mechanistic link explaining this association is the pattern of lipid partitioning in the face of excess calories and energy surplus. A tight relation exists between typical lipid deposition patterns, specifically within the skeletal muscle and liver, as well as the intra-abdominal compartment and whole body insulin sensitivity.
The metabolic syndrome (MetS), also known as ―Insulin Resistance Syndrome‖ or ―Syndrome X‖ describes clustering of established cardiovascular risk factors in specific individuals. These factors include altered glucose metabolism, elevated triglycerides, reduced HDL-cholesterol, elevated blood pressure and adiposity and have been shown to directly promote the development of atherosclerotic cardiovascular disease. While the exact definition of the syndrome in the pediatric age group is still debated, it is well-established that adults who meet the criteria for the syndrome are at increased risk for the development of type 2 diabetes (T2DM) and cardiovascular diseases over time, compared to individuals who do not meet these criteria.
Our study was aimed to assess prevalence metabolic syndrome in school aged obese children.
This cross-sectional study was conducted at Pediatric Endocrinology Unit, and Menoufia University Hospital on obese children 6-16 years (BMI ≥ 95th percentile). Obesity was defined as a BMI greater than the 95th percentile for age and gender.