الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: Pediatric onset multiple sclerosis (POMS), defined as an age at onset younger than 18 years, which occurs in 5% of patients with MS. cognitive dysfunction is one of the prominent disabling sequelae of Multiple sclero¬sis. Brain volumetric studies by magnetic resonance images revealed the decline of whole and regional brain volumes along the disease course. This work aimed to investigate the relationship between cognitive impairment in pediatric MS patients with thalamic atrophy and cortical thickness of temporal lobe. This study included 50 patients who were diagnosed as POMS and 50 healthy control participants matched for age and sex. Both groups were compared for volumetric measurements of thalamic volumes and temporal lobes cortical thickness using a computerized program called FreeSurfer.MS group was evaluated for cognitive dysfunction using Arabic version of fifth edition of Standford- Benit test. A correlation between volumetric results and neuropsychological evaluation of MS group was done. Results: Our study showed that the MS group has the lowest value regarding their thalamic volumes and their corti¬cal thickness of temporal lobes in relation to the healthy control group, while there was a significant relation between cognitive impairment and decrease in thalamic volume and specific areas in cortical thickness, such as superior temporal thickness, middle temporal thickness, inferior temporal thickness, fusiform thickness and para hippocampal thickness of temporal lobe in pediatric onset MS patients.
Conclusions: POMS affects specific brain areas such as thalamus and cortical thickness of temporal lobes regarding their volume and thickness which influence the neuropsychological evaluation detected by Standford-Benit test.