الفهرس 
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Abstract
The frequency of drug dependency among Egyptians aged 15 to 64 years old is 0.8%, according to the World Health Organization. Opioids were the primary drug of concern in 44% of instances of substance abuse.
An essential part of the motivational drive and dependent disorders is known to be craving. As a result, it has been defined as an overpowering and invasive desire to take a substance. It has been shown that non-pharmacological therapies including as 12-step rehabilitation, cognitive behavioral therapy, and mindfulness-based relapse prevention (MBRP) may reduce desire.
CBT, 12-step treatment, and mindfulness-based relapse prevention were compared in this study to see whether any of them had an impact on desire in opioid abusers.
Men with opioid dependence who met the DSM-5 criteria and were hospitalised to
El Maamora hospital participated in this randomised clinical experiment. The urine dipstick test proved that they had finished their detoxification at the treatment facility.
Participants were eliminated if they had major cognitive impairment, present suicidal thoughts, any organic ailment, or were taking any drugs that impact stress response and, thus, desire. Participants with these conditions were also removed.
The department of medical statistics at Alexandria Medical Research Institute established the study’s sample size. CIs for comparing groups in terms of the efficacy of mindfulness-based relapse prevention, cognitive behavioral therapy, or twelve-step treatment on opioid desire was 95% and the test power was 80 percent. In each group, at least fifteen members were required.
There were 75 people who were eligible for this randomized clinical study, however 15 of them were deemed ineligible. Using a computer-generated random number, trained employees at the clinic blindly allocated 60 eligible participants seeking for treatment to one of three treatment groups: CBT, MBRP, or twelve-step therapy; each group consisted of 20 subjects. A total of five patients in group one were unable to be tracked down after being released from the hospital. Two participants refused to take part in group two, while three others were not tracked down after being released from the hospital. Five people refused to take part in the third group. As a result, each group had a total of fifteen participants for the study.