الفهرس 
0 Evaluation of potential effects of anti-gout drug, zyloric on development of offspring of albino rats during lactation
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Abstract
Lactation, secretion and yielding of milk by females after giving birth. The milk produced by the mammary glands, which are contained within the breasts. The breasts, unlike most of the other organs, continue to increase in size after childbirth. Although mammary growth begins during pregnancy under the influence of ovarian and placental hormones, and some milk formed, copious milk secretion sets in only after delivery. Since lactation ensues after a premature birth, it would appear that milk production held back during pregnancy. The mechanism by which this inhibitory effect brought about, or by which lactation initiated at delivery, has long been the subject of an argument that revolves around the opposing actions of estrogen, progesterone, and prolactin. Relative to lactation; surprisingly little is known about the effects of glucocorticoid exposure on the developing fetus during lactation. One of the used corticosteroids in lactation is allopurinol. It is predominantly used for its anti-inflammatory effects, and treatment of gout. At present, no adequate data is available that as control to illustrate the safety use of allopurinol on the offspring during lactation, so in the present study we examine the offspring toxic effects of allopurinol on offspring if allopurinol was given orally at a recommended daily dose during lactation. Lactating albino rats (Rattus norvegicus) were administrated during lactation period with therapeutic dose. Offspring were examined after birth and evaluated for mortality rate, growth parameters, and morphological as well as histological study of liver, kidney and brain. During lactation, the morphological examination of the neonates showed that prednisone caused mild growth retardation represented by decrease in body weight, body length. Histopathological examination of the main vital organs liver, kidney and brain of neonates of the treated group on the seventh, fourteenth and twenty first days revealed that there was multiple hepatocytes exhibiting vacuolar degenerative changes with scattered necrotic cells and surrounding associated inflammatory cells in liver, in kidney shows Hepatic cell with pyknotic nuclei, fatty degeneration change, Central vein and erythroblasts were seen, brain shows increase in glomeruli, size within the Bowman’s capsule, shrinkage glomeruli and degenerated tubules, Lymphatic infiltration invasion, karyolysis and degeneration of epithelial cells lining the proximal and distal tubules.It is recommended not to use allopurinol during lactation period as it transfer through milk to fetus because some fetal problems affect there brain, liver and kidney