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العنوان
Analytical study of some drugs affecting nasal mucosa /
الناشر
Joliana Fawzy Farid Saleh ,
المؤلف
Joliana Fawzy Farid Saleh
هيئة الاعداد
باحث / Joliana Fawzy Farid Saleh
مشرف / Nadia Mohammed Mostafa
مشرف / Yasmin Mohammed Fayez
مشرف / Hebatallah Mohammed Essam
تاريخ النشر
2021
عدد الصفحات
185 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
29/01/2021
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

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from 221

Abstract

This thesis is concerned with the analysis of some drugs affecting nasal mucosa namely, Paracetamol with Phenylephrine hydrochloride andParacetamol with Pseudoephedrine hydrochloride and Chlorpheniramine maleate in their combined form. It comprises application of different methods of analysis for assay of the selected drugs in their mixtures and in pharmaceutical dosage forms. Moreover, stability indicating methods for some of the selected drugswere developed and validated in presence of degradation products and impurities due to their toxicity.The proposed methods were statistically compared with official methods to confirm the claims of methods{u2019} validity.The applied techniques include spectrophotometry, chemometry, thin layer chromatography (TLC), high performance liquid chromatography (HPLC), capillary electrophoresis (CE) and ion selective electrodes (ISE).The proposed methods were simple, accurate, and reproducible, which would be feasible and sensitive for the determination of the studied drugs