الفهرس 
Potential effect of ezetimibe on experimentally induced hypertensive nephropathy in albino rats
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Abstract
Background: Hypertension is considered one of the major risk factors for developing end-stage renal failure, as it is the second leading cause of end-stage renal disease.The damage that occurs to the kidney tissue due to hypertension involves most of the renal tissues. Current therapeutic strategies to prevent or revert renal disease progression focus on the reduction of urinary protein excretion and blood pressure control.Aim: The present study was designed to evaluate the possible protective effect of ezetimibe alone and in combination with lisinopril against experimentally induced hypertensive nephropathy in rats.Methods: Hypertensive nephropathy was induced in adult rats by administration of L- NAME (75 mg/kg/day) for 6 weeks. Rats were treated with either ezetimibe (3mg/kg/day), lisinopril (10mg/kg/day)in combination with L-NAME. Also, the effect of the combination of ezetimibe with lisinopril was tested. Body weight and mean arterial pressure were measured at 0, 2, 4 &6 weeks of the study. Urine albumin was measured at 3 & 6 weeks of the study. Serum urea, creatinine, interleukin 10 and vascular endothelial growth factor were also measured at 3 & 6 weeks of the study. At the end of the study, the thoracic aorta was isolated for studying phenylephrine induced contraction and acetylcholine induced relaxation. Finally, histopathological study was done for rats{u2019} kidneys in allgroups.Results: When compared with the -ve control group; chronic L-NAME administration resulted in significant elevation in the body weight, mean arterial pressure, serum urea, serum creatinine and albuminuria