الفهرس | Only 14 pages are availabe for public view |
Abstract Objective: This study was conducted to assess chemerien level and detect its role as a predictor for gestational diabetes mellitus by studying the relation between serum chemerin level in the first trimester and development of GDM. Background: Chemerin is an adipokine that regulate adipocyte development and metabolic function as well as glucose metabolism in liver and skeletal muscle tissue. Gestational diabetes mellitus (GDM) is defined as glucose intolerance first recognition during pregnancy. The incidence of GDM is increasing year by year all over the world, especially in developing countries. Patients and Methods: This Case control study has been conducted on atotal number of 162 patients, divided into two groups according to their BMI: group 1: normal weight group 2: Overweight, marked or morbid obese. Participants were selected from those attending obstetrics and Gynecology outpatient clinic Birket Al Sabaa hospital. Results: Based on past review of literature that assumed the prevalence of gestational diabetes to be (13.2%) sample size has been calculated and it will be 162 patients. Based on the current results gestational diabetes was diagnosed among 12.3% (20 patients), randomly 80 patients were chosen out of 142 free gestational diabetes ones to further analyze the data. Conclusions: Based on the results of the present study, we conclude that Serum chemerin level during the first trimester of pregnancy has potential to predict risk of GDM. The meta-analysis support chemirin as a novel biomarker for the early diagnosis of GDM, which affect many pregnant women. |