الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 120 |  |  |
| | | from | 120 | | |
Abstract
Introduction: Pre-eclampsia (PE) is a severe complication unique to human pregnancy with a worldwide incidence of 2–10%. Preeclampsiais one of the leading causes of fetal, maternal, and neonatal mortality and morbidity, even in countries.Alpha-Fetoprotein (AFP) is a glycoprotein produced by the secondary yolk sac, the fetal liver, and the gastrointestinal tract. The level of AFP enhanced by the combination of fetal production, clearance through the fetal kidney, and by any perturbation of the placental interface between the fetus and the mother.A research showed that elevated AFP, hCG, and inhibin A levels were associated with preeclampsia in preterm patients, and the more elevated they were, the higher the likelihood. It seems that prenatal screening biomarkers have the possibility to predict the preeclampsia. Aim of this study: The aim of the present study was to determine the association between maternal serum alpha-fetoprotein and pre-eclampsia and correlation between the severity of diseases and serum alpha-fetoprotein and effect on neonatal outcomes.Patients and methods: The present study was a case control retrospective study conducted on 62 (31 in each group) attending Mansoura University hospitals, Mansoura, Egypt for one year All patients in the present study were subjected to history taking, physical examination, routine laboratory investigations as complete blood count, blood group, RH, AST, ALT, Creatinine, hematological evaluation, Blood sugar. Assessment of Maternal serum alpha-fetoprotein.Results: •There was no statistically significant difference in the mode of delivery between the cases in the two study groups with CS represent the highest percentage in the two groups (71% and 58.1%) in the test and control group respectively.•the median level of alpha fetoprotein was statistically significantly higher in the test group as compared with the control group (p=0.001).•There was no statistically significantly difference in the incidence of postpartum haemorrhage between the two groups.•The incidence of premature infants and NICU were statistically significant higher in the test group as compared with the control group. There was no reported IUFD in the two study groups.• the best cutoff point of alpha fetoprotein level to identify the cases with preeclampsia was > 54 ng/ml with 74.2% sensitivity, 66.5% specificity and 66.4% accuracy. The prediction ability showed high statistically significant value (p <0.001).the median level of alpha fetoprotein in the cases with preeclampsia was 152 ng/ml with range between 15.9 and 255 ng/ml while in the cases with severe preeclampsia was 134.4 ng/ml with range between 28.6 and 843.6 ng/ml, with no statistically significant difference between the two groups (p=0.316).