الفهرس 
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Abstract
Infective endocarditis (IE) is a severe disease, associated with high morbidity and mortality. Despite improvements in diagnostic and therapeutic strategies, both the incidence and severity of the disease seem to be unchanged.
The aim of this work was to assess the clinical and echocardiographic profile and outcomes of patients diagnosed with IE in Alexandria University hospitals through an observational and non-interventional study.
This study included 90 patients who were admitted to Cardiology department - Alexandria university hospitals by the diagnosis of infective endocarditis
• All patients were evaluated by history taking, clinical examination, routine laboratory investigations and 12-lead ECG.
• Echocardiographic data was recorded regarding vegetation(s) size(s), abscess, pseudo-aneurysm, valvular and perivalvular lesions, valve regurgitation or stenosis, as well as complete standard echocardiographic studies. Both TTE and TEE were performed as indicated.
• In-hospital events and mortality as well as one year mortality was recorded.
1) Observational data:
a. Patients diagnosed with infective endocarditis were young, mean age was 37 years and the majority of them were males.
b. The most common pre-existing cardiac condition is the valvular heart disease and the most common risk factors were smoking and IV drug abuse.
c. Negative blood cultures were encountered in 54% of the patients and the most common bacteria isolated was MRSA (24%).
d. All the patients received the guidelines directed medical therapy as per the ESC guidelines for infective endocarditis.
2) In-hospital morbidity and mortality:
a. Persistent fever was the most encountered problem in the hospitalized patients (42.22%) followed by embolic complication (32.22%) and the most common sites of embolism was cerebrovascular (8.89%) and lower limbs (8.89%).
b. Surgery was indicated in 91.11% of patients and it was performed in only 28.89%. In-hospital mortality was significantly more in those who did not underwent surgery (87.1% Vs 12.9%) (P<0.001) and the most common cause of failure to perform surgery was the death of patients before the surgery (30%).
c. In-hospital mortality was 34.44% and the most common cause was a combined cardiogenic and septic shock.