الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 135 |  |  |
| | | from | 135 | | |
Abstract
This thesis is divided into three chapters, introduction, synthesis of some heterocyclic imidazolidine compounds and biological activity of some nitrogen heterocyclic compounds. Chapter I: Introduction This chapter contains literatures review of imidazolidinone derivatives for the last years .Chapter II: Synthesis of some nitrogen heterocyclic compounds This chapter deals with the synthesis of thiohydantoin derivatives. The author tend to synthesis of thiohydantoins starting from 1-acetylferrocene (1) that was converted into the corresponding 1-[(ferrocene-1-ylethylidene)amino]-thiourea (2) using thiosemicarbazide. Treatment of the thiourea derivative (2) with ethyl chloroacetate yield the corresponding 3-[(ferrocene-1-ylethylidene)amin o]-2-thioxo-imidazolidine-4-one (3). Furthermore, compound (2) undergoes coupling reaction with phenacyl bromide in the presence of fused sodium acetate in acetic acid to give the corresponding 4-phenyl-3-[(ferrocene-1-ylethylidene)amino]-imidazolidine-2-thione (4) which was converted to 1-acetyl-3-[(ferrocene-1-ylethlidene)amino]-4-phenyl-imidazolidine-2-thione (8) via the actylation with acetic anhydride (Scheme 1). Ferrocenyl-thiohyantoin (3) was either converted into the 1-acetyl-3-[(ferrocene-1-ylethylidene) amino]-4-hydroxy-imidazolidine-2-thione (5) through boiling in acetic anhydride or reacted with two different aromatic aldehydes (a, b) in piperidine to yield the corresponding ferrocenyl-thiohyantoin arylidenes, 3-[(ferrocene-1-ylethylidene) amino]-2-thioxo-5-arylidene-imidazolidine-4-ones (6a, b). The ferrocenyl-thiohyantoin arylidenes (6a, b) were further acetylated with acetic anhydride to afford the corresponding 1-acetyl-2-thioxo-3-[(ferrocene-1-ylethylidene)amino]-5-arylidene-imidazolidine-4-ones (7a, b) (Scheme 2). Chapter III: Biological activity of some nitrogen heterocyclic compounds Antimicrobial activities of the prepared compounds (2-8) were investigated using agar well diffusion method. Antibacterial activity was studied against the bacillus subtilis and staphylococcus aureus as gram positive bacteria, while Escherichia coli and pseudomonas aeruginosa as gram negative bacteria.The zone of inhibition was measured compared with standard drug (ciprofloxacin). The inhibition zone was measured compared with fluconazole as standard drug, and using DMSO as a blank as antifungal activity. The cytotoxic activities of prepared compounds were tested against HepG-2 cell line according to method of Masmann and Vijayen et al. Compounds 2 and 4 showed antitumor activity than the standard antitumor drug against HepG-2 cell line.