الفهرس 
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Abstract
Iron deficiency anemia remains a major worldwide health problem in the 21st century. It continues to affect the health, quality of life and working capacity of approximately two billion people all over the world. IDA is responsible for around 50% of all cases of anemia worldwide. It can occur at all stages of life and is most prevalent in high-risk individuals, such as children, adolescents and women during childbearing age.
IDA is influenced by diet, iron intake, blood loss, physiological status and infections. Genetic factors also play an important role in iron status, and recent genome wide association studies have found associations between the presence of genetic variants and iron status biomarkers.
Some studies have found that SNPs located in the intronic region of CACNA2D3 gene significantly associated with hemoglobin and ferritin as well as with different probabilities of belonging to different iron clinical phenotypes.
CACNA2D3 gene is located on locus 3p21.1 of chromosome 3. It encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
The aim of this study was to assess the association between SNP rs1375515 of CACNA2D3 gene and iron deficiency anemia in some Egyptian women at the age of child bearing period.
The study was conducted on 80 subjects classified into two groups; group 1 included 40 females in child bearing period with iron deficiency anemia and group 2 included 40 age and sex related healthy controls.
Our study results showed that there was no statistically significant association between rs1375515 SNP and red blood cell indices in anemia patients including HGB, HCT, MCV and MCH. P values were 0.090, 0.574, 0.958 and 0.606 respectively.
Also, log Serum iron and log ferritin values were compared between anemic patients with CC genotype and those with CT or TT genotype, and no statistically significant difference is found. P values were 0.568 and 0.556 respectively.