الفهرس 
الصفحة الاولى العنوان باللغة الانجليزيةOnly 14 pages are availabe for public view
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Abstract
Cancer is a key health issue across the world, causing substantial patient morbidity and mortality ranking as a leading cause of death. Cancer is the first or second leading cause of death before the age of 70 years in 112 of 183 countries and ranks third or fourth in a further 23 countries reflecting changes in the prevalence and distribution of the main risk factors for cancer. Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are highly organized and interconnected organ systems. Tumorigenesis and cancer formation is a complex multistep process involving genetic, epigenetic, and metabolic alterations, and interactions with complex microenvironment that transform normal cells into malignant ones. As part of this process, oncogenes get activated, and tumor suppressor genes get repressed, affecting cell proliferation,