الفهرس 
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Abstract
Sepsis is a complicated syndrome resulting from the inappropriate expression of
host factors in response to infection and is a major cause of death in patients that are
hospitalized, in emergency departments (ED) and in critical care units.
The purpose of the present study is to detect the possible association between
baseline levels of Interleukin 10 & soluble CD 25 and early (7 days) sepsis associated
mortality in addition to detection of correlation between baseline levels of Interleukin 10
& soluble CD 25 and other clinic laboratory variables in non-survivors in a cohort of
Egyptian adults with sepsis.
The evaluation and management of sepsis was consistent with the 2016 guidelines
issued by the Surviving Sepsis Campaign.
This study applied on 70 adults with sepsis and was done at Menoufia university
hospitals.
The present study revealed the following results:
Mean age of included patients was 60 years, 60% of them were males, while 40%
females.
Pulmonary primary site of infection was found in 44% of patients.
41.4% of patients needed mechanical ventilation.
Within studied patients, non-survival is highly significantly associated with lung
infection.
Regarding clinical data, non-survival is highly significantly associated with
frequency of using ventilator than survivors.
IL-10 and sCD25 are highly significantly higher in non-survivor cases than
survivors.
APTT, CRP, WBC are highly significantly higher in non-survivor cases than
survivors.
On the other hand, platelet is highly significantly lower in non-survivor cases than
survivors.
SOFA score is significantly higher in non-survivor cases than survivors.
There is statistically highly significantly positive correlation between SOFA score
and each of IL-10, sCD25.
On the other hand, there is negative correlation between SOFA score and level of
platelet.
There is statistically highly significantly positive correlation between biomarkers
IL-10&sCD25 and laboratory investigations (APTT, CRP, WBC). there is also
statistically highly significant negative correlation between biomarkers IL-
10&sCD25 and level of platelets.
By logistic regression analysis it was found that there is highly significant positive
correlation between non-survival and each of using ventilator, levels of IL-10,
sCD25, SOFA score and laboratory results of CRP, WBC.
On the other hand, there is highly significant negative correlation between nonsurvival
and platelets level.
Sepsis triggers the production of a diverse array of cytokines that are proinflammatory
and anti-inflammatory. While pro-inflammatory cytokines are
necessary for controlling infection, their excessive production may lead to tissue
and organ injury.
The initial serum levels of IL-10 as the prognostic value of the outcome of patients
with sepsis is expected to more comprehensive sepsis treatment to prevent
complications and deaths.
IL-10 and sCD25 gave a significant contribution to prognostic evaluation and
early diagnosis of sepsis. SOFA score appeared to be a reliable prognostic tool in
this subset of patient.
The results of this study open doors for:
More clarifying the sepsis scene via larger scale, longer time studies with
reporting more sepsis outcomes alongside, the evaluation of other or additional
proinflammatory & anti-inflammatory biomarkers would be recommended.
Keeping pace with times extra polation of this kind of studies to patient with
(covid-19 sepsis) is almost substantial.
We hope for near future molecular researches to decode the precise roles of
proinflammatory & anti-inflammatory proteoms in sepsis pathology, hence
opening doors for drug discovery, therapeutic trials, hoping to improve sepsis
outcomes.