الفهرس 
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Abstract
Vitiligo is a common autoimmune disease in the skin, hair and/or mucus membranes in which melanocytes are destroyed. The global prevalence of vitiligo ranges between 0.5 to 2%, and more than half of the cases are diagnosed before 20 years Toll like receptors regulate innate as well as adaptive immunity by activating pathogen associated molecular patterns (PAMPs) that are found on various pathogens. By stimulating these receptors, many cellular processes are triggered including the production of various inflammatory cytokines, antigen presentation, phagocytosis, and recruitment of immune cells As regard TLR2, there have been several single-nucleotide polymorphisms (SNPs) detected in the TLR2 gene. One of these polymorphisms is the TLR2 Arg753Gln polymorphism (R753Q, rs5743708), a missense single-nucleotide polymorphism that occurs in the TLR2 peptide when arginine is substituted for glutamine. A previous study in Turkey found that Arg753Gln decreased intracellular signaling pathways and was associated with vitiligo TLR4 has an Asp299Gly polymorphism in exon 4 that affects its signaling and has been linked to many autoimmune diseases, urinary tract infections and colorectal cancer. In a study conducted in Turkey, polymorphisms of TLR4 (Asp299Gly) were found among patients with vitiligo The Aim of this study: In this study, the aim was to investigate the possible association between TLR gene polymorphism and vitiligo. Materials and methods: A case control study was carried out on 100 patients recruited from our patients’ clinic of Dermatology, Andrology and STDs department, Mansoura University Hospital, suffering from vitiligo with exclusion of other systemic and skin conditions. The control group consisted of 100 age and sex matched healthy individuals. Results: The current revealed that:For TLR-2 rs-5743708, allele ‘A’ was statistically significantly higher in cases (30%) vs. controls (18%) and genotypes G/A and A/A were statistically significantly higher in cases (50%) vs. controls (33%) respectively. For TLR-4 rs-4986790, allele ‘G’ was higher in cases (32%) vs. controls (28%) but this difference was not statistically significant. Also, genotypes A/G and G/G were higher in cases vs. controls (56 vs. 52) while A/A genotype was lower in cases vs. controls (44 vs. 48). However, this difference was not statistically significant (c2 = 0.322, P = 0.570). For TLR-4 rs-4986791, allele ‘T’ was statistically significantly higher in cases (27%) vs. controls (16%) and genotypes T/T and C/T were statistically significantly higher in cases (49%) vs. controls (30%).Conclusion: Our study showed that:TLR2 Arg753Gln polymorphism is associated with increased risk of vitiligo. Patients with allele ‘A’ and genotypes G/A or A/A have higher risk for vitiligo TLR4 Thr399Il2 polymorphism is associated with increased risk of vitiligo. Patients with allele ‘T’ and genotypes T/T or C/T have higher risk for vitiligo TLR4 Asp299Gly polymorphism isn’t associated with increased risk of vitiligo.Keywords: vitiligo, toll like receptors, polymorphism .