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العنوان
Diffuse Alopecia:
المؤلف
Sheikh Adan, Aisha Bashi.
هيئة الاعداد
باحث / عائشة بشير شيخ ادن
مشرف / هدى احمد محمد منيب
مشرف / نجلاء سمير احمد
مشرف / مروه ياسين احمد سلطان
تاريخ النشر
2022.
عدد الصفحات
118 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الأمراض الجلدية
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة عين شمس - كلية الطب - قسم الامراض الجلدية
الفهرس
Only 14 pages are availabe for public view

from 118

from 118

Abstract

from the current study, we concluded that:
• Telogen effluvium, female pattern hair loss as well as combined cases of both entities are the frequent causes of acute diffuse hair loss in females.
• Studying the trichoscopic features and recognition of trichoscopy signs are fundamental to reach the appropriate the diagnosis as they share some shared features.
• Histological studies derive a tool to reach the appropriate diagnosis when the trichoscopic features are insufficient.
• Despite the infrequent occurrence of alopecia areata incognita in comparison to TE, and FPHL, it should be always considered and its trichoscopic and histopathological features should be kept in consideration in the differential diagnosis of any cases presenting with acute diffuse hair loss.
RECOMMENDATIONS
from the current study, we can recommend the following:
• Larger scale studies with longer enrollment periods are needed to cover and come across different topics involved in acute diffuse hair loss.
• Studying the effect of different systemic or topical treatments on the trichoscopic features of cases with acute diffuse hair loss as well as the disease progression and course.
SUMMARY
H
air disorders represent an important field of research for dermatologists and many of them are common in everyday clinical practice. The most important hair diseases are divided in noncicatricial and cicatricial ones, and they have different clinical, dermoscopic, histological and therapeutic characteristics. Two of the most common causes of noncicatricial diffuse hair loss in females are FPHL and TE.
In the current study we aimed to study the clinical, trichoscopic findings, histopathological in patients with acute diffuse hair loss. In addition, immunohistochemistry analysis for CD3 was done for differentiation and detection of the prognostic values of these markers.
The current study included 40 female patients with acute diffuse hair shedding in the last 6 months. All patients were subjected to full history recording, general and local examination of the scalp. Hair examination of the scalp was performed using trichoscopic assessment and scalp biopsy. Based on the trichoscopic assessment, the patients were categorized into 3 groups; patients with TE, patients with FPHL, and patients with combined TE and FPHL.
Trichoscopic assessment of our studied cases revealed that hair diameter diversity was significantly demonstrated in FPHL patients compared to the other two groups. The number of thin hairs in frontal area, number of hair units with one hair, hair shaft diameter differences between different scalp sites and number of vellus hairs were significantly demonstrated in FPHL and TE+ FPHL patients compared to TE patients. Peripilar sign and empty hair follicles in frontal area were significantly presented in FPHL patients compared to other two groups.
On the other hand, short regrowing hair was significantly presented in TE patients and TE+ FPHL patients compared to FPHL patients. TE demonstrated the highest detectable hair shaft thickness followed by cases of TE combined with FPHL and then cases with FPHL with the lowest diameter.
Regarding histological studies, there was no statistically significant difference between the three groups enrolled in the study; TE, FPHL, TE+FPHL; regarding the lymphocytic infiltrate at different sites from the hair follicles.
Finally, the current study demonstrated the value of trichoscopic examination in the differentiation of different causes of diffuse hair loss as FPHL and TE.