الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Osteoarthritis is one of the most common joint disorders worldwide being far more common than rheumatoid arthritis and other forms of joint disease. It is costly and disabling with an endpoint of total loss of joint cartilage in the affected area and the need for joint replacement.
The etiology of OA is still unclear, multiple lifestyle and environmental factors are considered to significantly contribute to its risk. Also, the role of specific genes is under investigation as, the results of heritability studies in twins, sibling and families have shown that genetic factors are estimated to contribute up to 50% of the risk for developing OA.
Research showed that ADAMTS14 gene is involved in the formation process of collagen fiber II which is one of the main components of joint cartilage extracellular matrix. The abnormal metabolism of collagen fiber II leads to a decreased mechanical strength of joint cartilage which is one of the important factors affecting joint arthritis. Another gene, DVWA is thought to be involved in cellular adhesion and protein to protein interactions
The aim of this study was to investigate the association between primary knee OA with ADAMTS14 gene rs4747096 and DVWA gene rs11718863 SNP in a cohort of Egyptian patients and to analyze the relationship between these genetic polymorphisms with the severity of knee OA. Also, to assess the association between hand OA and its severity with these genetic polymorphisms.