الفهرس 
Introduction and rationaleOnly 14 pages are availabe for public view
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Abstract
The impact of asthma on the quality of life of patients, as well as its cost, is very high. Therefore, appropriate asthma management may have a major impact on the quality of life of patients and their families, as well as on public health outcomes. The ‘hygiene hypothesis’ postulates that the rise of allergic disease in recent decades is attributable to a decrease in exposure to certain microbes and infections during childhood, and has gained wide acceptance.
H. pylori may have a beneficial effect through a pivotal influence in the immunological response especially in asthma.
So our aim of the current case-control study was to evaluate the relation of H. pylori infection in children with asthma, a condition linked with chronic inflammation.
The present study is case control study. This study recruited 50 Asthmatic children attending outpatient clinic, ER and admitted in the inpatient of Suez Canal university hospital, Ismailia general hospital and health insurance hospital. The included patients were matched with 50 non asthmatic children.
All asthmatic children were be subjected to carful history taking, physical examination and this was fulfilled in our questionnaire and All asthmatic and control cases had Serum analysed for anti-H. pylori cytotoxin associated gene A (CagA) IgG antibody using commercially available ELISA kits and total serum IgE level using commercially available ELISA kits.
The included patients, the mean age of groups were 7.9(±1.7) years and 7.8 (±1.9) years, respectively. Two groups were comparable as regard age and gender which indicate good matching as p value >0.05.
Cases have mean onset of disease of 3.4±1.5 years ranged from 2 to 7 years. More than half of patients (52%) have family atopy and 38% have other atopy. Regarding asthma severity classification 52% were intermittent, 34%