الفهرس 
COVID 19Only 14 pages are availabe for public view
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Abstract
Background: Covid-19 is a disease with high morbidity and mortality among elderly residents of long-term care facilities (LTCF). During an outbreak of SARS-CoV-2 infection in the LTCF an effective screening tool is essential to identify the patients at risk for severe disease. Excessive interleukin-6 signaling is a key factor contributing to the cytokine release syndrome implicated in clinical manifestations of COVID-19.
Aim of the Work: To determine the Role of interleukin 6 as predictive factor for the severity of Covid-19.
Patients and Methods: This was Case Control study, conducted at Abassia Fever hospital and El Demerdash University Hospital on 75 participants (50 patients with Covid-19 disease manifestation and 25 controls) during a period of 6 months.
Results: There was no statistically significant difference between cases with less than 50% and more than 50% lung affection among mild cases groups as regard serum IL-6.
Conclusion: The concentration of IL-6 > 24 pg/mL at initial assessment predicted the development of hypoxemia requiring hospitalization with excellent sensitivity and good specificity. IL-6 appears as a potential predictor for the development of the severe Covid-19 and might serve for early identification of patients in need of hospitalization. Further studies are needed to evaluate the robustness of the use of IL-6 as an effective screening tool for the severe course of Covid-19.