الفهرس 
SepsisOnly 14 pages are availabe for public view
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Abstract
Sepsis is a life-threatening condition that arises when the body’s response to infection injures its own tissues and organs. According to the American College of Chest Physicians and the Society of Critical Care Medicine, there are different levels of sepsis: sepsis, severe sepsis, and septic shock.
The mortality rate of SIRS, sepsis, severe sepsis and septic shock is high, ranging from approximately 10% in SIRS to 60% in septic shock. While identification and treatment of sepsis has led to a decrease in mortality, the incidence continues to increase resulting in a still larger number of deaths annually. Worldwide, sepsis is thus the major cause of death in intensive care units (ICU) and therefore an area of concern.
In order to improve the survival of patients with SIRS and sepsis, it is essential to identify the individuals at high risk. One approach for this identification is constantly evaluating reliable biological markers. Diagnostic markers should be able to accurately detect the disease early in its course while prognostic markers must predict the progression of the disease. Procalcitonin and CRP are biological markers currently in clinical use for detection of infection and unspecific inflammation, respectively, in the therapeutic management of SIRS and sepsis.
Patients with sepsis indicated that low ApoAV levels are associated with higher mortality, but the association became non-significant after adjusting for HDL-C levels. However, little is known about the role of ApoAV in pediatric patients with sepsis.
Our aim in this study was to assess reliability of Apolipoprotein A-V as a diagnostic and prognostic value for sepsis in pediatric intensive care unit of Menoufia University.