الفهرس 
Introduction and RationaleOnly 14 pages are availabe for public view
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Abstract
Oxidative stress has been suggested to play a possible role in the development of β-hemoglobinopathies (sickle cell anemia and thalassemia), glucose-6-phosphate dehydrogenase deficiency, hereditary spherocytosis, congenital dyserythropoietic anemia and Paroxysmal Nocturnal Hemoglobinuria. The oxidative damage to the erythroid cells plays a crucial role in hemolysis due to ineffective erythropoiesis in the bone marrow and short survival of red blood cells. Moreover, Oxidative stress is believed to aggravate the symptoms of such disorders.
The present study aimed at assessing the levels of oxidative stress markers (hydrogen peroxide and malondialdehyde) and anti-oxidants (superoxide dismutase) among patients with chronic hemolytic anemia compared to healthy controls.
Accordingly, our case control study included two groups:
i) Children with chronic hemolytic anemia 1-15 years old presented to Suez Canal university hospital hematology unit (n= 50), and
ii) Healthy volunteers age and sex matched with the study group presented to Suez Canal University hospital outpatient clinic (n=50) who served as a normal control group.
The results of our study were as the following:
o Children with chronic hemolytic anemia showed significantly