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Abstract The present study intended to investigate seasonal variations of antioxidant activity of some seaweeds collected from Abu Qir Bay, Alexandria, Egypt. Furthermore, we select the best algae with the best solvent in each season depend on the antioxidant assays and complete the other assays on them (DPPH radical scavenging activity, primary metabolites estimation, composition of fatty acids, estimation of secondary metabolites, antidiabetic, anticancer and anti-inflammatory activities). The methanol extract of Jania rubens and Padina pavonia was selected to complete the in vivo anticancer, anti-inflammatory and antihepatotoxic tests as the two extracts were recorded the highest in the in vitro assays. Furthermore, the present study evaluated the efficiency of seaweeds collected from Abu Qir Bay, Alexandria, Egypt, as a feedstock for biodiesel. The obtained results can be summarized in the following points: 1. A total of 18 macroalgal species were collected overall in the four seasons. The highest seasonal total antioxidant activity (44.6±1.6 mg ascorbic acid equivalents/g crude extract) and ferric reducing antioxidant power (FRAP) assay (32.3±0.0 mg ascorbic acid equivalents/g crude extract) were observed with ethanol extract of Toania atomaria in spring season. |