الفهرس 
Biological Basis of OsteogenesisOnly 14 pages are availabe for public view
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Abstract
Background: Traumatic bone loss poses a serious problem for orthopedic surgeons added to the long standing risk of infection implied by open type fractures.
Aim of the work: This study aims to assess the efficacy of distraction osteogenesis in compensating bone defects using the Paley score for functional and radiological outcomes.
Methodology: We searched the literature through PubMed database with publication date restricted to 10 years range from 2009-2019 English literature of prospective studies only were selected with strict inclusion criteria where repeated articles were excluded unless they presented follow up with functional outcome data about cases. Seven studies were included satisfying the predetermined inclusion criteria with total of 242 cases. Patients’ data were collected and analyzed with only: 176 cases mentioned demographic data with average age of ‘37’ and no comorbidities to decrease the risk of bias in our results. 125 patients had fractures in tibia without soft tissue loss and 51 patients needed skin grafting, 3.4% of total cases underwent late amputation, 14.2% experienced pin tract infection.
Results: Our results appear to demonstrate the efficacy of mono-focal distraction osteogenesis technique in compensating long bone defects of the lower limbs in traumatic events. We isolated studies reporting exclusively on either proximal tibia or distal tibia bone defects compared the respective outcomes of interest in the absence of statistical heterogeneity. The only significant difference that could be established was a four-fold decrease of the likelihood of fair functional results in the ‘distal tibia’ subgroup compared with the ‘proximal tibia’ subgroup. In distal tibial defects, we explored the impact of the size of a bone defect and duration of external fixation on outcomes of interest. We noticed a 3.7-times increase in the odds of re-fracture when the size of the distal tibial defect exceeded 8 cm
Conclusion: Mono-focal distraction osteogenesis (Ilizarov method) is effective in managing bone defects larger than 3 cm² however for defects larger than 8cm² there’s increased risk of re-fracture.