الفهرس 
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Abstract
Summery
When searching for adjuvants to conventional periodontal treatments, the recent interest is the relationship between antioxidants and periodontitis, so the present study was designed to prove this correlation. The aim of the present study was to investigate the effect of use of antioxidants as adjuncts in treatment of periodontitis, and to estimate whether antioxidants have some beneficial effect on the treatment of periodontitis or not.
Hence the study evaluated the effect of selenium ACE anti-oxidant drug on the levels of salivary uric acid anti-oxidant and on periodontal index in patients having chronic gingivitis and periodontitis disease in conjunction with non-surgical periodontal thereby.
This study was interventional, clinical trial, conducted on 75 subjects (42 males and 33 females) from Al-Azhar University, Medical administrator department, boy’s branch, out clinic patients. The selected subjects were divided according to Community Periodontal Index of Treatment Needs into 5 groups, 15 members for each:
group I- normal clinically healthy gingiva (receive no treatment)
group II-gingivitis patients who were treated non surgically
group III- gingivitis patients who were treated non surgically with antioxidants supplementation.
group IV- chronic periodontitis patients who were treated non surgically.
group V- chronic periodontitis patients who were treated non surgically with antioxidants supplementation.
At the baseline, periodontal attachment loss was recorded using RUSLE periodontal index, scaling and root planning was performed in gingivitis and periodontitis groups, oral hygiene instructions including brushing and interdental brushing were given at baseline and reinforced at each recall visit.
Antioxidants supplementations were administrated randomly to group III & V in the form of Selenium-ACE® single daily tablets taken orally for two weeks (Vitamin A 1500 IU + Vitamin E 22 IU + Vitamin C 90 mg + Selenium 55 ug). Saliva samples were collected at baseline, 15th day, 30th day, and 45th day for evaluation of uric acid levels.
Statistical analysis shows that uric acid levels were significantly low in patients with more destructive periodontitis as compared to clinically healthy and gingivitis groups. As the treatment was initiated, significant increase in uric acid levels was observed as the time elapsed.
Therefore, the present study indicates that antioxidants may have a beneficial adjunctive role to non-surgical periodontal therapy
Furthermore, more longitudinal studies with larger sample size coupled with other inflammatory markers are required to establish this role.