الفهرس 
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Abstract
Diabetes mellitus is characterized by organ dysfunction arising from the effects of chronic hyperglycaemia. The chronic complications of diabetes are classified as macro- or microvascular depending on the underlying pathophysiology. The. Inflammation plays an essential role in the progression of diabetic complications. Recently, new markers have been studied in the pathogenesis of diabetes and its complications such as lipopoly saccharide binding protein.
LBp is a 60-kD glycoprotein produced in hepatocytes as a 50-kD single-chain polypeptide LBP is present in normal serum at 0.5 fig/ml, increasing to 50 ig/ml 24 hours after an acute phase response is induced
The aim of this study was to Evaluate the plasma level of lipopolysaccharide binding protein in patients with T2DM and to Study the association between plasma level of lipopolysaccharide binding protein with insulin resistance and beta cell function in patients with T2DM.
This case control study was conducted on 90 adult subjects divided into two groups: group A included 45 patients with type 2 diabetes with a mean disease duration7.46 ± 5.03years and mean age was54.53 ± 9.29 years group B included 45 normal subjects with mean age 51.53 ± 10.94years
T2DM subjects were recruited from the outpatient clinic of the Diabetes and metabolism unit at Alexandria Main University hospital. Patients with Type 1 diabetes mellitus, Sever renal or hepatic impairment, Acute or chronic infection, chronic inflammatory disease, Hematological or malignant disease and Recent surgery or severe burn were excluded from the study. Moreover, pregnant females were also excluded.
Full informed consent was taken from all study participants and they were subjected to a full medical history assessment and complete physical examination insulin resistance and beta cell function was estimated by using Homeostasis model assessment (HOMA2) calculator according to the updated computer based HOMA 2 model. And Serum Lipopolysaccharide binding protein was measured by ELISA technique.
The results of the present work pointed out the significant high level of mean serum LBP in T2DM patient s( 81.95 ± 32.98)than normal subjects (65.73 ± 9.52).
Also, this work pointed out that serum LBP levels is strongly associated with obesity as BW, WC and BMI are in positive significant correlation with serum LBP levels in diabetics and non-diabetics.
In non-diabetics, in addition to obesity serum LBP is positively correlated with HbA1C, FI, HOMA2, serum TG levels BW duration of diabetes.
The results of the present work pointed out the strong association between serum LBP levels and insulin resistance in diabetics.
Multivariate analysis show that HOMA2, waist circumference and diabetes duration was independently associated with serum LBP levels