الفهرس 
Chapter 1: General introductionOnly 14 pages are availabe for public view
 |  | from | 99 |  |  |
| | | from | 99 | | |
Abstract
Marine natural products have attracted the attention of biologists and chemists around the world. Marine world represents a large, unexplored wealthy resource; hence, there is a great potential to discover chemotherapeutic agents. Fresh water also contains a big diversity of organisms which produce several bioactive compounds such as crabs, shrimps, algea and cyanobacteria etc.
Obesity is a global health problem that has become an epidemic; it is considered one of the primary causing factor for deaths worldwide. Therefore, scientists always search for a solution to avoid obesity side-effects and consequences. Several therapeutic options are now available such as healthy diet, sport, behavior modification, pharmacotherapy, and surgery. Natural products (NPs) and also their structural analogues have a major contribution to pharmacotherapy through history. NPs active ingredients can play anti-obesity role as follows 1) helping in nutrient absorption. (2) Enhancing the energy expenditure and decreasing the adipogenesis. (3) Modifying the intestinal microbiota, increasing the fat excretion and suppressing the appetite
In this study, fresh water crab (Potamonautes niloticus) that was collected from the river Nile of Egypt was used. The crab MeOH: DCM extract was analyzed using spectrometric techniques, such as 1D and 2D HNMR and LCMs-MS in Sweden. The NMR results showed that the extract contains long chain fatty acids, phospholipids, amino acids and sugars.
The LCMs-MS results were analyzed using the Global Natural Products Social molecular networking (GNPS) database. The identified compounds were amino acids such as ( cyclo-(Ala-4-hydroxy-Pro), ile-pro, Isoleucyl-Proline, cyclo-(Leu-Leu), Cycloleucylleucine, Valyl-Leucine, L-valyl-L-phenylalanine, Cyclo(L-leucyl-L-phenylalanyl), cyclo-[Tyr-(4-hydroxy-Pro)], and Leucyl-phenylalanine). Long chain unsaturated fatty acids such as (9-octadecenoic acid, 13-keto-9Z,11E-octadecadienoic
English Summary
Marine natural products have attracted the attention of biologists and chemists around the world. Marine world represents a large, unexplored wealthy resource; hence, there is a great potential to discover chemotherapeutic agents. Fresh water also contains a big diversity of organisms which produce several bioactive compounds such as crabs, shrimps, algea and cyanobacteria etc.
Obesity is a global health problem that has become an epidemic; it is considered one of the primary causing factor for deaths worldwide. Therefore, scientists always search for a solution to avoid obesity side-effects and consequences. Several therapeutic options are now available such as healthy diet, sport, behavior modification, pharmacotherapy, and surgery. Natural products (NPs) and also their structural analogues have a major contribution to pharmacotherapy through history. NPs active ingredients can play anti-obesity role as follows 1) helping in nutrient absorption. (2) Enhancing the energy expenditure and decreasing the adipogenesis. (3) Modifying the intestinal microbiota, increasing the fat excretion and suppressing the appetite
In this study, fresh water crab (Potamonautes niloticus) that was collected from the river Nile of Egypt was used. The crab MeOH: DCM extract was analyzed using spectrometric techniques, such as 1D and 2D HNMR and LCMs-MS in Sweden. The NMR results showed that the extract contains long chain fatty acids, phospholipids, amino acids and sugars.
The LCMs-MS results were analyzed using the Global Natural Products Social molecular networking (GNPS) database. The identified compounds were amino acids such as ( cyclo-(Ala-4-hydroxy-Pro), ile-pro, Isoleucyl-Proline, cyclo-(Leu-Leu), Cycloleucylleucine, Valyl-Leucine, L-valyl-L-phenylalanine, Cyclo(L-leucyl-L-phenylalanyl), cyclo-[Tyr-(4-hydroxy-Pro)], and Leucyl-phenylalanine). Long chain unsaturated fatty acids such as (9-octadecenoic acid, 13-keto-9Z,11E-octadecadienoic