الفهرس 
Introduction & Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Reviewing the current literature, hepatocellular carcinoma (HCC) has become one of the most common cancers and the top cause of cancer-related mortality in the world. Several advances in the therapeutic strategy have been made in recent decades, not just for early but also for later stages of HCC. HCC occurs in the context of a chronic liver disease that eventually leads to liver fibrosis and cirrhosis, both of which are HCC major risk factors. Hepatitis C and B, aflatoxins, alcoholic liver disease and NAFLD are all commonly encountered chronic inflammatory hepatopathologies that predispose to HCC. Therefore, the present study includes : I: Induction of hepatocellular carcinoma by thioacetamide injection : Rats were injected with TAA (dissolved in sterile water for injection) at a dose of 200 mg/kg by intraperitoneal (i.p.) injection two times per week for 14 successive weeks. The success of the HCC model was confirmed after 14 weeks by collecting serum for analysis of alpha-fetoprotein (AFP) level and then sacrificing ten rats selected randomly from those receiving TAA. The liver was isolated from these rats for histopathological examination. II: Evaluation of the protective effect of SeNPs and QCT through the measuring of : 1 – Liver function parameters. 2 – Anti-oxidant activity. 3 – Inflammatory biomarkers.