الفهرس 
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Abstract
Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by thrombocytopenia that results from platelet autoantibodies, leading to an accelerated clearance of opsonized platelets by phagocytes. The etiology of ITP is still not clear, both genetic and environmental factors might play a role in the development of such disease. It has been reported that several gene polymorphisms influence host susceptibility to ITP.
The aim of this study was to investigate the association of single nucleotide polymorphism (SNP) in the gene of SDF1 RS 2839693 with ITP in Egyptian children patients.
We have analyzed 60 cases with ITP (28 males and 32 females) together with 90 healthy controls from Beni -suef university Hospital, Health insurance hospital Beni -suef.
Our results demonstrated that there was no statistically significant difference in either genotype or allelic distribution between ITP patients and controls furthermore ,there was statistically significant association between GG, AA genotype carriers and therapeautic response to steroid (p value <0.05 ) but there was no other association between other genotype carriers and other lines of treatment . but there was no other association between other genotype carriers and other lines of treatment , clinical picture or history data.
Also, no significant association was determined between various genotype carriers (GG, GA, AA) of SDF1 gene and the chronicity of the disease . This study concluded that there is no association between SDF1 gene rs2839693 and susceptibility to develop ITP in pediatric patient . but
there is significant association with steroid dependency.However, there was no significant relation between various genotype carriers and disease activity ( chronicity of the disease).