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Abstract neoplastic disorders. Fine Needle Aspiration Cytology (FNAC) is simple, quick, inexpensive and minimally invasive OPD technique used for establishing the etiology of cervical lymphadenopathy. In recent years, ultrasound-guided core needle biopsy (CNB) has been highlighted as being a more effective tool for obtaining sufficient material from a lymph node from which to diagnose cervical lymphadenopathy. In comparison with FNAC, CNB has the disadvantages of being associated with high-risk complications, such as an overall high rate of hematoma, the procedure is painful, and there is an increase in the potential for seeding malignant cells along the needle tract. In addition, FNAC can be performed without equipment in most palpable nodes, but CNB requires ultrasound to avoid complications and to ensure suitable targeting. The aim of this study was to assess the accuracy, specificity and sensitivity of core biopsy in establishing tissue diagnosis of enlarged cervical lymph nodes. Statistical analysis revealed the following: 1- Out of 25 cases, 10 were found to be non neoplastic lesions (40%), where as 15 cases (60%) were found to be neoplastic. 2- There are 8 cases (32% of the total) turned out to have Metastatic lymph node from thyroid cancer, whereas 5 cases (20%) had granulomatous lymphadenitis, 4 cases (16%) had Non-Hodgkin’s lymphoma, 3 cases had Hodgkin’s lymphoma in the neck (12.0%), 1case was diagnosed as Metastatic lymph node from parotid cancer (4%) and 1 case was found out to be a case of Nodular sclerosis lymphoma (4%). 3- The mo |