الفهرس 
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Abstract
Pesticides are agents used to eradicate pests in many fields to protect crops from damage. Imidacloprid is a new type of insecticide, and it belongs to a novel active group, nitroguanidine. Imidacloprid has a potent insecticidal action. It is one of the popular insecticides worldwide. The mechanism of imidacloprid action differs from that of the organophosphorus compounds, carbamates, and pyrethroids.
Imidacloprid has selective toxicity resulting from its high affinity to the insect’s nicotinic acetylcholine receptors compared with mammals. Different studies pointed to the IMD toxicity on various organs as the heart, kidney, immune system and CNS. Recently; IMD- induced reproductive toxicity gained attention. In veterinary medicine, imidacloprid is used to eradicate fleas on pets and houseflies.
Some researchers claimed that chronic exposure to the high dose of IMI in humans and animals is associated with mutagenesis, teratogenesis, and carcinogenicity. Limited researches evaluated IMI-induced oxidative damage on reproductive organs. The testicular tissue is affected by the releases of free radicals and lipid peroxidation by IMI.
Imidacloprid-induced oxidative stress pointed to antioxidants as protective agents that could mitigate imidacloprid-induced toxicity. Vitamin C has proven to have a vital role in insecticide toxicity protection, especially in hepatic toxicity. It is an antioxidant agent that prevents the effect of ROS on vital cells.
This study aimed to evaluate the potential histological changes and cyto-genotoxicity induced by imidacloprid on albino mice’s, as a mammalian model and the possible protective effect of vitamin C.
This research was carried out on 70 male albino mice’s, aged 2-3 months their body weight ranged from 30-40 grams. They were obtained from the animal house centre, Faculty of Medicine, divided into three main groups: (group I): 30 mice serving as a control group, (group II): Included 20 mice, (group III): Included 20 mice. It extended for 28 days. On the 28st day, all the animal groups were subdivided into two subgroups (a- b).