الفهرس 
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Abstract
Cirrhosis, the end stage of liver fibrosis, is one of the world’s most serious health problems. It is linked to an increased risk of morbidity and mortality, which has serious health and social implications. It is characterized by the accumulation of excess collagen and extracellular matrix in response to chronic liver cell damage and is the ultimate pathway for many chronic liver diseases.
The hepatotoxin thioacetamide (TAA) is a very efficient, dependable, and satisfying model for developing liver cirrhosis in laboratory animals. It is used in various doses to induce liver cirrhosis, extreme bile duct proliferation, and cholangiocarcinoma at different intervals.
Quercetin (QR) is one of the most studied flavonoids, with excellent free radical scavenging properties. It has potent antioxidant and cytoprotective properties, as well as anti-inflammatory, hepato-protective, reno-protective, and neuro-protective properties.
The present study aimed to estimate the hepatoprotective effects of the flavonoid QR against TAA-induced liver cirrhosis in adult male rats using histological, immunohistochemical, biochemical and morphometric studies.
The current study was carried out on forty male albino rats assigned to four groups as follows:
1. group I: Control group (n= 10); C rats were given sodium chloride 0.9% (1mg/kg, single dose) by intraperitoneal injection twice weekly for eight weeks.
2. group II: Quercetin group (n= 10); QR rats were treated with quercetin (50 mg/kg/day) orally for eight weeks.
3. group III: Thioacetamide group (n= 10); TAA rats were treated with thioacetamide in a dose of 200 mg/kg, by intraperitoneal injection twice weekly for eight weeks.
4. group IV: Thioacetamide & quercetin group (n= 10); TAA/QR rats were treated with thioacetamide in a dose of 200 mg/kg, by intraperitoneal injection twice weekly and quercetin (50 mg/kg/day) orally for eight weeks.