الفهرس 
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Abstract
The present study was assessed to detect effect of Nigella Sativa on amoxicillin clavulanic acid induced liver damage in Rats which were bought from laboratory animal house in helwan. A total of 72 adult male rat were included in this study for 3 weeks and they were devided into 6 groups as following: Control group in which rats were served as non-treated group (control). 1st group: rats were given the therapeutic dose of amoxicillin clavulanic acid (150 mg/kg b,wt.) by intramuscular injection for 7 days. 2nd group: rats were given therapeutic dose of amoxicillin clavulanic acid (150 mg/kg b,wt.) I.M for 7 days and low dose of Nigella Sativa oil (1 ml/kg b,wt.) orally for 21 day. 3rd group: rats were given therapeutic dose of amoxi-clav. (150 mg/kg b.wt) I.M for 7 days and high dose of Nigella Sativa (2 ml/kg b.wt) orally for 21 day. 4th group: rats were given therapeutic dose of Nigella Sativa oil (1 ml/kg b,wt) orally for 21 day. 5th group: rats were given the therapeutic dose of amoxicillin clavulanic acid (150 mg/kg b,wt) by intramuscular injection for 7 days then stop the amoxi-clav. and give Nigella Sativa oil with therapeutic dose (1 ml/kg b,wt) orally for 14 day. Blood samples were collected weekly started from one week after stop of treatment and persisted for three weeks. After 21 consecutive days of treatment, all rats were sacrificed and liver specimens were collected for histopathological examination. The biochemical analysis of serum of clinically healthy mature rats was carried out to estimate liver function tests (ALT, AST, total protein, albumin and bilirubin), kidney function tests (creatinin), total antioxidant, malondialdehyde and lipid profile. The obtained data reflected that a significant increase in serum ALT, AST activities, albumin, total protein, cholesterol and CRP levels in G1 that received amoxicillin clavulanic acid. Moreover, the recorded data revealed a significant decrease in ALT, AST, CRP, creatinine, total antioxidant, triglyceride, cholesterol, HDL, LDL and MDA levels in groups that received Nigella Sativa with or without the drug. It also should be mentioned that NS showed no effect on total protein and bilirubin levels in different groups. Histopathological examination of hepatic tissue showed hepatic damage as a result of treatment with AC (150mg/kg/day). On the other hand combined treatment with AC (150mg/kg/day) & NS (1ml&2ml/kg/day) or with NS alone (1ml/kg/day) produced marked protection for hepatic tissue.