الفهرس 
List of ContentsOnly 14 pages are availabe for public view
 |  | from | 107 |  |  |
| | | from | 107 | | |
Abstract
The use of routine uterotonics in prevention and management of postpartum hemorrhage has a wide range. This study was carried out to compare the efficacy of buccal misoprostol versus intravenous oxytocin in prevention of post-partum hemorrhage. Methods: A randomized controlled trial (RCT) study double blind started by 154 patients at term (37-40 weeks) gestation scheduled for elective cesarean delivery, who were assigned to either buccal misoprostol 400 ug or intravenous infusion of 5 IU oxytocin IV space after anaesthesia, then evaluated as regards their base line data, laboratory data, operative, post-operative data, neonatal outcome, need for other uterotonic drugs, complication and blood loss parameters. Results: The patients’ baseline and operative data were matched between the two studied groups (P>0.05).Both techniques were equally effective in Operative and Post-operative investigations with no significant difference between the two studied groups. Change in Hb level were significantly increase in 400 μg buccal misoprostol group than in oxytocin group (p=0.011). There was a need for additional oxytocin therapy after use of misoprostol and oxytocin. The overall mean blood loss was significantly lower in the misoprostol group compared to the oxytocin group (461.69±72.54mL vs. 432.6±88.58; p = 0.02).Difference in weight of towels (gm)between the two groups was statistically significant (209.35±40.76vs 193.51±46.5ml, p< 0.0001).Incidence of side effects such as fever and chills were significantly higher in the misoprostol group compared to the oxytocin group (p < 0.001).