الفهرس 
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Abstract
Sepsis is a serious life-threatening condition and a leading cause of morbidity and mortality in full and pre-term infants, especially in the developing countries. It is broadly defined as a systemic inflammatory response occurring in the first 28 days of life as a result of a suspected or proven infection.
Laboratory indicators, such as complete blood-cell count, ratio of immature to total neutrophil and C- reactive protein (CRP) do not have high sensitivity especially if measured early in the course of sepsis. Thus, early identification of infants with bacterial sepsis has been recognized to be a major diagnostic challenge.
Because PTX3 may be a faster acute-phase protein that is not liver-dependent, it is probable that it is superior to traditional biomarkers for mirroring rapid inflammatory courses. Compelling indications are present that a high serum concentration of PTX3 predicts shock, poor outcome, and organ failure in meningococcal disease and severe sepsis, respectively, in children and adults.
Aprospectivecase control study design was used to determine the role of pentraxin3, mean platelet volume, neutrophil-lymphocyte ratio, and platelet lymphocyte ratio in the diagnosis of neonatal sepsis to allow more accurate diagnosis.
This study was carried out on neonatal ICU unit of pediatric department in Suez Canal University Hospital. The studied patients were divided into two groups, including patients diagnosed with neonatal sepsis, full term neonates of both sexes, diagnosed with neonatal sepsis based on clinical, laboratory and positive blood culture results, and whose clinical findings included the presence of three or more of the following :temperature instability (hypothermia, hyperthermia),respiratory alterations (grunting, intercostal retractions,apnea, tachypnea, cyanosis),