الفهرس 
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Abstract
Vitiligo is the most common pigmentary disorder worldwide affecting 0.5-2% of the world’s population, irrespective of race and gender. It is a chronic skin condition that causes loss of pigment, resulting in irregular pale chacky white or milky patches of skin. Present vitiligo therapies require long time of treatment and often result in disappointing outcomes.
5-Fluorouracil is a chemotherapeutic agent used in the treatment of a wide variety of malignancies. It has been noticed that localized hyperpigmentation occurred as a side effect during using 5-FU in cancer treatment that is what brought the attention toward using 5-FU in inducing repigmentation in vitiligo patches.
Microneedling is used as a method of transdermal drug delivery to increase the absorption of topical immunomodulator drugs. This technique is used to augment the absorption of drugs, enhance the efficacy, and decrease the period of therapy.
We conducted this study to identify the efficacy and safety of treating vitiligo by microneedling followed by application of 5-FU on vitiligo patches, and to evaluate the immunohistochemical expression of MMP-2 in involved skin in vitiligo patients before and after treatment. In addition to correlate clinical response and MMP-2 expression with the clinicopathological parameters in those patients.
This study was conducted on 20 patients suffering from vitiligo. For all participants, history taking and clinical examination and two skin biopsies submitted to H&E stain and imunohistochemical staining for MMP-2 before and after treatment (microneedling and 5-FU) were performed. This treatment procedure was applied every 2 weeks for 6 sessions.