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Abstract The present experiment was performed to determine the side effects of levofloxacin, and evaluate the possible protective effects of curcumin and ginger against adverse effects of levofloxacin in rats, through determination of hematological parameters (RBCs count, Hb, PCV, MCV, MCH, MCHC, platelets count, total and differential leukocytes count), liver function tests, aidney function, and antioxidant /oxidant status in the liver and kidney tissues (GPX, SOD and MDA). After two weeks of acclimatization, seventy two male albino rats were divided into six equal groups each of twelve rats as following: group 1: Rats were given distilled water (0.2ml/kg b.wt.) and kept as control for 5 conscutive days. group 2: Rats were orally administered olive oil (0.2ml/kg b.wt.) as a vehicle for 5 consecutive days and kept as control. group 3: Rats received levofloxacin (10 mg/kg b.wt.) and used as positive control group. group 4: Rats were received levofloxacin (10 mg/kg b.wt.) and Vitamin E (100 mg/kg b.wt.) 2 hours before levofloxacin for 5 conscutive days. |