الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 134 |  |  |
| | | from | 134 | | |
Abstract
Bisphenol A (BPA) is an organic synthetic compound and a major environmental pollutant. It is widely used to manufacture numerous consumer products. BPA is an endocrine disruptor and interferes with hormone function. It has been linked to cardiovascular disease, brain development abnormalities, obesity, hypertension, thyroid dysfunction, diabetes, breast cancer, infertility, and other health problems. It was reported that BPA can cause harmful effects in cells and tissues.
Quercetin is a polyphenolic flavonoid; it is ubiquitous in plants and plant food sources. It is one of the most abundant nutritional flavonoids found in fruits (mainly citrus fruits), green leafy vegetables, as well as many seeds. It is well known for its antiinflammatory, antihypertensive, vasodilator, anti-obesity, anti-hypercholesterolaemic, and anti-atherosclerotic activities. Quercetin’s antioxidant properties play an important role in the prevention and treatment of these diseases. In addition, Quercetin can also demonstrate a strong antioxidant activity due to its high solubility and bioavailability.
So, the aim of this work was to investigate BPA toxicity in liver and kidney of male rats and its possible amelioration on quercetin treatment.
In this study six groups (6 animals /each) of rats are assigned and treated as following:
” group I (control) was orally administered with carboxy methyl cellulose.
■ group II was orally administered with a dose equal 50 mg/kg of body weight of quercetin.
■ group III was orally administered with a dose equal 25 mg/kg of body weight of BPA.
* group IV was orally administered with a dose equal 50 mg/kg of body weight of BPA.
■ group V was orally administered with a dose equal 25 mg/kg of body weight of BPA and 50 mg/kg of body weight of quercetin.
■ group VI was orally administered with a dose equal 50 mg/kg of body weight of BPA and 50 mg/kg of body weight of quercetin.
Doses of BPA (25 and 50 mg/kg b.wt) were prepared by dissolving in carboxy methylcellulose and Q (50 mg/kg b.wt) was prepared by dissolving in carboxy methylcellulose and adjusted according to rat’s body weights and given orally by gavages approximately at the same time each morning, 6 days per week for 4 weeks.
The present study revealed that there was insignificant change in the finally body weight in all groups administered with bisphenol A and/or Quercetin when compared with control group. The liver weight and liver relative weight insignificantly changed in all groups administered with Bisphenol A and/or Quercetin when compared with control group. Also, kidney weight and kidney relative weight insignificantly changed in all treated groups administered with bisphenol A and/or quercetin when compared with control group. The obtained results revealed that Hb, Ht and RBCs significantly decreased in the treated group Bis50 only and insignificantly changed in all other groups when compared with control group.Meanwhile, the co-administeration of Q returned back the levels of Hb, Ht and RBCs to its normal values as control group.