الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusion The β-thalassemias are genetic disorders of hemoglobin synthesis characterized by deficient or absent synthesis of the β-globin subunit of hemoglobin molecule. The relative excess of α-globin results in the formation of insoluble aggregates leading to ineffective erythropoiesis and shortened red cell survival. A relatively high capacity for fetal hemoglobin synthesis is a major genetic modifier of disease severity (26). Thalassemia is the most common form of inherited anaemia world wild. the world Health organization reports that about 60.000 infants are born with a major thalassemia every year.it represents a major public health problem in Egypt with a high rate of carriers ranging from 4-5% reaching up to 9-10% (118). Blood group antigens are either sugars or proteins are attached to various components in the red blood cell membrane. The ABO blood group antigens remain of prime importance in transfusion medicine. Numerous associations have been made between particular ABO phenotypes and an increased susceptibility to disease. For example, the ABO phenotype has been linked with stomach ulcers (more common in group O individuals) and gastric cancer (more common in group A individuals)(133). The aim of this work was To outline the blood group frequencies of families of children with beta Thalassemia and To detect, Is there any hematological abnormalities associated with this disease. The present study was carried out on 20 families (88 subjects) of patients of Beta thalassemia who are treated at Tanta University hospitals, with there age ranging from 1-42 years. All subjects underwent complete history taking, complete physical examination and the following investigations: A complete blood count (CBC).