الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The synthesized thiazolidine-2,4-dione derivatives were screened via MTT assay for their cytotoxic activities against normal human cells (Wi-38) to assess their safety profiles and all compounds were safer than the reference chemotherapy doxorubicin. Moreover, the studied compounds were subjected to anticancer evaluation via MTT assay against human colon cancer Caco-2 cells compared to doxorubicin as reference chemotherapy. Compounds 225 (IC50; 4.41 μM), 23c (IC50; 4.71 μM) and 221 (IC50; 4.73 μM) exhibited the highest anticancer potentials among the evaluated derivatives.The most promising anticancer 2,4-thiazolidinedione derivatives 221, 23c and 225 inhibited Aldehyde dehydrogenase 1 family, member A1 (ALDH1A) by 95.84%, 85.92% and 86.48%, respectively in the treated Caco-2 cells. Furthermore, the compounds also suppressed the antioxidant activity of glutathione peroxidase (GPX) by 87.03%, 50.17% and 53.28% in Caco-2 cells after 72 h incubation, respectively.