الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Ulcerative colitis (UC) is a recurrent bowel disease resulting from uncontrolled inflammation that ultimately leads to mucosal disruption and ulceration. Medicinal plants have played a key role in world health in spite of great advances observed in conventional medicine in recent decades, herbal medicine still makes an important contribution to health care. For centuries, M. oleifera has been used as a traditional medicinal source. employed for the treatment of many diseases, and therefore, it was called a “miracle vegetable”. Currently, M. oleifera is reported to enhance a broad range of biological functions, So the bioactivity of M. oleifera has gained tremendous attention over the last decade. Also Psychological disorders such as depression have more prevalence in inflammatory bowel disease patients and can exacerbate the clinical course of the disease, so anti-depressant therapy may have a potential to positively impact the disease course. On the other hand several antidepressant drugs have shown anti-inflammatory and immunomodulatory properties. Therefore, an attempt was made to investigate the possible prophylactic and therapeutic effects of Moringa oleifera and fluoxetine on dextran induced colitis in male wistar rats in comparison with the reference drug Sulfasalazine using the following biomarkers including (MPO, MDA, NO, GSH and TNFα). The results showed that both Moringa oleifera and fluoxetine have significant prophylactic and therapeutic activity against experimental colitis in rats, as indicated by biochemical and histological evaluations. Moringa oleifera seems to be the most effective as prophylactic therapy on the other hand fluoxetine seems to be the most effective as Curative therapy.
Key words: Ulcerative colitis, Moringa oleifera, fluoxetine, dextran