الفهرس 
Anemia in chronic Kidney DiseaseOnly 14 pages are availabe for public view
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Abstract
Patients on standard dialysis, in particular those on high-flux and high-efficiency dialysis, are exposed to hundreds of liters of dialysis-water per week. The quality of dialysis-water is a factor responsible for inflammation which is a potent trigger of atherosclerosis and a pathogenic factor in anemia, increasing mortality and morbidity in these patients. Current systems for water treatment do not completely eliminate bacteria and endotoxins. Our study tests if improved dialysis-water purity by using Central dialysis Fluid Delivery System (CDDS) can reduce inflammation and ameliorate hemoglobin levels.
Objective: The aim of this work is to compare between the effect of using Central Dialysis Fluid Delivery System (CDDS) and Single Dialysis Fluid Delivery System (SDDS) on Anemia in prevalent Hemodialysis Patients.
Patients and Methods: 150 patients were enrolled in this study. The laboratory tests, sonographic and endoscopy findings of 150 CLD patients to assess their correlation to esophageal varices. The Patients were classified into two groups according to the presence of varices and ascites into EV group of 75 cirrhotic patients with esophageal varices regardless of ascites, and Non EV: group of 75 patients with chronic liver disease and no ascites on sonography as a control group. The esophageal varices group were further subclassified into 3 groups according to the grade of varices present. Patients with grade I varices were assigned to group (EV 1). Patients with grade II varices (EV 2). Patients with grade III varices were included in (EV 3) group.
Results: The present study is a cohort study which was conducted in the period from May 2019 to July 2019 of 100 prevalent HD patients recruited from Mansheiyat El Bakry General Hospital and Ainshams University Hospital to study the impact of Dialysis Fluid Delivery system on Anemia in HD Patients. Descriptive statistics was done for quantitative data as minimum& maximum of the range as well as mean±SD (standard deviation) for quantitative normally distributed data, while it was done for qualitative data as number and percentage.
K-S (….) test was used for normality testing, independent t-test in cases of two independent groups with normally distributed data and paired t-test in cases of two dependent groups with normally distributed data. In qualitative data, inferential analyses for independent variables was done using Chi square test for differences between proportions. The level of significance was taken at P value < 0.050 is significant, otherwise is non-significant.
Conclusion: Ultrapure dialysis fluid (UPD) produced by the Central dialysis fluid delivery system (CDDS) compared to the SPDDS dialysate, was reflected positively on minimizing the inflammatory status of this group of patients causing a significant sustained improvement in their hemoglobin level, ERI and a decrease in their ESA requirements.